ea0015p331 | Steroids | SFEBES2008
Ivison Hannah E
, Shenoy Savitha
, Arlt Felix J
, Krone Nils
, Shackleton Cedric HL
, Taylor Norman F
, Arlt Wiebke
CYP17A1 is a key enzyme of human steroidogenesis, which is unique in that it catalyses two reactions, 17-hydroxylase activity converting pregnenolone and progesterone to 17-hydroxypregnenolone (17Preg) and 17-hydroxy-progesterone, respectively, and 17,20 lyase activity, responsible for the conversion of 17Preg to dehydroepiandrosterone the crucial precursor of human sex steroid biosynthesis. 17-hydroxylase deficiency, a variant of congenital adrenal hyperplasia, results in glu...